South Bend is a city in, and the county seat of, St. Joseph County, Indiana, on the St. Joseph River near its southernmost bend, from which it derives its name. As of the 2010 census, the city had a total of 101,168 residents; its metropolitan statistical area had a population of 318,586 and its combined statistical area, 721,296. It is the fourthlargest city in Indiana, and is the economic ...